Fatty acid degradation
Lipid
Scientists halt brain disease with new gene therapy...said. Featured in the 1992 movie "Lorenzo's Oil," ALD is a rare hereditary condition caused by a deficiency of a protein involved in fatty acid degradation. Sufferers gradually lose the myelin sheath, a protective layer coating the... In this article: HIV, Leber congenital amaurosis, Leukemia, Dementia, X-linked adrenoleukodystrophy, Rare disease, Fatty acid degradation, Severe combined immunodeficiency, and Lorenzo's Oil |
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Wikipedia | November 02, 2009
Fatty acid degradation
Fatty acid degradation is the process in which fatty acids are broken down into their metabolites, resulting in release of its energy to the target cells. It includes three major steps: Lipolysis of and release from adipose tissue
In this article: Carnitine, Fatty acid, ATP, Acyltransferase, Lipolysis, Thioester, Acyl-CoA, Pyrophosphate, and Malonyl-CoA
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Wikipedia | October 10, 2009
Fatty acid metabolism
...to ~ 1 mM. Thus, serum albumin transports fatty acids to organs such as muscle and liver for oxidation when blood sugar is low. Fatty acid degradation is the process in which fatty acids are broken down, resulting in release of...
In this article: Fatty acid, Triglyceride, Cholesterol, Acetyl-CoA, Lipoprotein, Carbon, Carbohydrate, Lipolysis, Insulin, and Hormone
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Wikipedia | August 09, 2009
Unspecific monooxygenase
...participates in 7 metabolic pathways : fatty acid metabolism, androgen and estrogen metabolism, gamma-hexachlorocyclohexane degradation, tryptophan metabolism, arachidonic acid metabolism, linoleic acid metabolism, and metabolism of...
In this article: Unspecific monooxygenase, Oxygen, Oxidoreductase, Arachidonic acid, Androgen, Linoleic acid, Hydrocarbon, Fatty acid metabolism, and Estrogen
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Wikipedia | August 09, 2009
Glutarate-CoA ligase
...name of this enzyme class is glutarate:CoA ligase (ADP-forming). Other names in common use include glutaryl-CoA synthetase, and glutaryl coenzyme A synthetase. This enzyme participates in fatty acid metabolism and lysine degradation.
In this article: Ligase, Phosphate, ATP, Glutarate-CoA ligase, Thiol, Glutaryl-CoA, Coenzyme, Carbon, Lysine, and Fatty acid metabolism
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Wikipedia | August 08, 2009
Butyryl-CoA dehydrogenase
...2,3-oxidoreductase. This enzyme participates in 3 metabolic pathways : fatty acid metabolism, valine, leucine and isoleucine degradation, and butanoate metabolism. It employs one cofactor , FAD. As of late 2007, two...
In this article: Dehydrogenase, Oxidoreductase, Coenzyme, Butyryl-CoA dehydrogenase, Butyryl-CoA, Acyl-CoA, Leucine, Isoleucine, and Fatty acid metabolism
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Wikipedia | August 08, 2009
Acetyl-CoA C-acetyltransferase
...acetyl-CoA:N-acetyltransferase, and thiolase II. This enzyme participates in 10 metabolic pathways : fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan...
In this article: Acetyltransferase, Acetyl-CoA, Coenzyme, Acetyl-CoA C-acetyltransferase, Transferase, Acetoacetyl-CoA, 2-methylacetoacetyl-coa, Lysine, Leucine, and Isoleucine
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PR Newswire: All Releases | November 18, 2008
Metabolex Announces Positive Results from Phase 2 Clinical Trial of MBX-8025
...apparent pattern of side effects associated with the drug." MBX-8025 is a potent, selective PPAR-delta agonist that helps to regulate fatty acid degradation, lipid storage/transport and insulin sensitivity. MBX-8025 is being developed to...
In this article: Atorvastatin, LDL Cholesterol, Dyslipidemia, Insulin, Cholesterol, HDL Cholesterol, Controversies, and Diabetes
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PR Newswire: All Releases | November 03, 2008
Two Metabolex Projects Recognized in Windhover's Top 10 Lists for Partnering Opportunities
...exenatide, however, MBX-2982 can be delivered orally. MBX-8025 MBX-8025 is a potent, selective PPAR-delta agonist that helps to regulate fatty acid degradation, lipid storage/transport and insulin sensitivity. MBX- 8025 is being developed to...
In this article: Windhover, Insulin, Glp-1, Exenatide, Incretin, Gpr119, and Dyslipidemia
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PR Newswire | September 24, 2007
Metabolex Begins Phase 2 Trial of MBX-8025 for Treatment of Dyslipidemia
...and body weight and composition. Metabolic parameters, including glucose and insulin levels, will also be assessed. MBX-8025 regulates fatty acid degradation, lipid storage/transport and insulin sensitivity. Metabolex has in-licensed the...
In this article: Dyslipidemia, Insulin, Triglyceride, Cholesterol, Statin, Atorvastatin, Obesity, Lipoprotein, and Glucose
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www.sciencedaily.com
Gene Therapy Technique Slows Brain Disease ALD Featured In Movie 'Lorenzo's Oil'
...in the movie "Lorenzo's Oil," ALD is a severe hereditary condition caused by a deficiency of a protein called ALD that is involved in fatty acid degradation. Sufferers steadily lose their myelin sheath, the protective layer that coats...
In this article: Vector, Lentivirus, HIV, Retrovirus, Adrenoleukodystrophy, Lorenzo's Oil, University Paris, Parkinson's disease, and American Association
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Description from Wikipedia:
Fatty acid degradation is the process in which fatty acids are broken down into their metabolites, resulting in release of its energy to the target cells. It includes three major steps:
*Lipolysis of and release from adipose tissue,
*Activation and transport into mitochondria,
*β-oxidation
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