Antibody
Protein
Advanced Leukemia Successfully Treated With First Use Of Antibody And Stem Cell TransplantationAdvanced Leukemia Successfully Treated With First Use Of Antibody And Stem Cell Transplantation Also Included In: Radiology / Nuclear Medicine; Stem Cell Research; Clinical Trials / Drug Trials Article Date: 07 Nov 2009 - 0:00 PST For... In this article: Leukemia, CD45, Myelodysplastic syndrome, Antibody, Medical advice, Iodine, University of Washington School of Medicine, and Chronic myelogenous leukemia |
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PR Newswire: Health / Biotech | December 08, 2008
Data Presented at ASH Annual Meeting Indicates the Potential of T-Cell Engaging BiTE Antibody Blinatumomab as a Consolidation Treatment for Aggressive Leukemias
Data Presented at ASH Annual Meeting Indicates the Potential of T-Cell Engaging BiTE Antibody Blinatumomab as a Consolidation Treatment for Aggressive Leukemias Empty Data Presented at ASH Annual Meeting Indicates the Potential of T-Cell...
In this article: Blinatumomab, Cancer, Adecatumumab, Leukemias, Acute lymphoblastic leukemia, Targeted therapy, Chemotherapy regimens, Breast cancer, and American Society of Hematology
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L.A. Times - Booster Shots | October 15, 2009
Viral link to prostate tumors questioned
...than quarter of human prostate tumors, particularly those that are most aggressive. Antibodies against the virus have also been found in as many as 95% of patients with chronic fatigue syndrome, suggesting that the mysterious virus,...
In this article: Cancer, Germany, Retrovirology, Leukemia, Chronic fatigue syndrome, Antibodies, University of Utah, and Los Angeles Times
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Medical News Today | August 15, 2008
Clinical Data Published In 'Science' Show Tumor Regressions In Relapsed Lymphoma Patients Treated With T Cell Engaging BiTE Antibody Blinatumomab
Clinical Data Published In 'Science' Show Tumor Regressions In Relapsed Lymphoma Patients Treated With T Cell Engaging BiTE Antibody Blinatumomab Lymphoma / Leukemia News Clinical Data Published In 'Science' Show Tumor Regressions In...
In this article: Blinatumomab, Cancer, Adecatumumab, Hodgkin's lymphoma, Acute lymphoblastic leukemia, Monoclonal antibodies, MedImmune, and Leukemia
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ScienceDaily: Latest Science News | July 09, 2009
New Treatment Avenue For Acute Myeloid Leukemia?
...such therapies may be possible." Journal reference: Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor %u03B1 Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells. Cell Stem Cell, July 2, 2009 Adapted from materials...
In this article: Cancer, Acute myeloid leukemia, Leukemia, Cd123, and Myeloid leukemia
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Revealing Leukemia-Initiating Cells
...levels predicted worse overall survival, they report. Antibodies against CD47 allowed the cancer stem cells to be eaten by macrophages and prevented them from taking hold in mice. Anti-CD47 treatment of mice with human leukemia also...
In this article: CD47, Leukemia, Cancer, Cell, Irving Weissman, Stanford University, Acute myeloid leukemia, Medical advice, and Targeted therapy
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Wikipedia | October 23, 2009
Thymidine kinase
...the rate of cell proliferation influences the TK values correspondingly. Antibodies against thymidine kinase are available for immunohistochemical detection. Staining for thymidine kinase was a reliable technique for identification of...
In this article: Thymidine, Thymidine kinase 1, Zidovudine, Ganciclovir, Leukemia, Deoxyuridine, Cancer, Lung cancer, Deoxythymidine monophosphate, and Phosphate
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Immunotherapy With Leukemia-cell-derived Heat Shock Protein 70 Triggers Induction Of Leukemia-specific Antibodies
Immunotherapy With Leukemia-cell-derived Heat Shock Protein 70 Triggers Induction Of Leukemia-specific Antibodies Article Date: 24 Jul 2008 - 1:00 PDT Even after chemotherapies and stem cell transplants, relapses still occur in leukemia...
In this article: Leukemia, Cancer, Peptide, Antibodies, and Chronic myelogenous leukemia
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Micromet Presents Safety And Efficacy Data From Primate Studies With Two New BiTE Antibodies Developed For Treatment Of Leukaemia And Melanoma
Micromet Presents Safety And Efficacy Data From Primate Studies With Two New BiTE Antibodies Developed For Treatment Of Leukaemia And Melanoma Lymphoma / Leukemia News Micromet Presents Safety And Efficacy Data From Primate Studies With Two...
In this article: Melanoma, Leukemia, Cancer, Antibodies, Adecatumumab, Hodgkin's lymphoma, Chronic myelogenous leukemia, Breast cancer, and American Association for Cancer Research
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Gene Therapy Activates Immune System In Patients With Leukemia
...more specific target for antibody therapy. Antibodies that target ROR1 would be unlike currently used antibodies, which bind antigens found not only on leukemia cells, but also on normal cells. Because they can destroy normal cells, the...
In this article: Leukemia, University of California, San Diego, Cancer, Antibodies, Chronic myelogenous leukemia, Myeloid leukemia, and Leukemia and Lymphoma Society
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Description from Wikipedia:
Antibodies (also known as immunoglobulins, abbreviated Ig) are gamma globulin proteins that are found in blood or other bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses. They are typically made of basic structural units - each with two large heavy chains and two small light chains - to form, for example, monomers with one unit, dimers with two units or pentamers with five units. Antibodies are produced by a kind of white blood cell called a B cell. There are several different types of antibody heavy chains, and several different kinds of antibodies, which are grouped into different isotypes based on which heavy chain they possess. Five different antibody isotypes are known in mammals, which perform different roles, and help direct the appropriate immune response for each different type of foreign object they encounter.
The large and diverse population of antibodies is generated by random combinations of a set of gene segments that encode different antigen binding sites (or paratopes), followed by random mutations in this area of the antibody gene, which create further diversity. Antibody genes also re-organize in a process called class switching that changes the base of the heavy chain to another, creating a different isotype of the antibody that retains the antigen specific variable region. This allows a single antibody to be used by several different parts of the immune system. Production of antibodies is the main function of the humoral immune system.
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