Fragile X syndrome
Disease
Seaside Therapeutics Raises $30M To Develop First Drugs That Work for Autism, Fragile X...has the potential to create the first drugs that treat the underlying neurological disorder at work in patients with Fragile X syndrome and autism. Seaside raised the money from a private, family investment firm that wishes to remain... In this article: Autism, Fragile X syndrome, Venture capital, MIT, Twitter, and National Institutes of Health |
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Xconomy | September 23, 2009
Biogen Idec Still Pursuing Facet Acquisition, Helicos Gets $10M Reprieve, Seaside Collects $30M for Autism Drug Development, & More Boston-Area Life Sciences News
...research from the lab of MIT neuroscientist Mark Bear into treatments that address the underlying neurological causes of Fragile X syndrome and autism. Founded in 2005, Seaside has never needed venture capital, according to CEO Randy...
In this article: Biogen Idec, Autism, Cancer, Helicos Biosciences, Nasdaq, Cambridge, Boston, SEC, CHL Medical Partners, and Versant Ventures
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www.washingtonpost.com | December 18, 2007
Fragile X Syndrome Corrected in Mice
...loss of the gene for "fragile X mental retardation protein" (FMRP). It affects about 100,000 people in the United States and is also a leading known genetic cause of autism. There is currently no treatment or therapy for fragile X syndrome.
In this article: FMRP, Autism, M.I.N.D. Institute, University of California, Davis, and MIT
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Medical News Today | November 03, 2009
Clinical Tests Begin On Medication To Correct Fragile X Defect
...problems, including learning disabilities and cognitive impairment. People with Fragile X syndrome may have anxiety and attention deficit hyperactivity disorder. About one-third of males with Fragile X syndrome also have autism or...
In this article: FMR1, National Institute of Mental Health, Massachusetts, Medical advice, Mental retardation, Autism, and Anxiety
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Seaside Therapeutics Initiates Clinical Development Of Novel Treatment For Fragile X Syndrome
...and pharmacokinetics of STX107 in healthy volunteers. Fragile X Syndrome is the most common inherited form of mental impairment and the most common known cause of autism. "Individuals with Fragile X and other related brain...
In this article: Autism, FMR1, Anxiety, National Institute of Mental Health, Medical advice, and National Institute of Neurological Disorders and Stroke
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Novel Research Deconstruct Inner Workings Of The Brain
...recognizes and processes facial data in typical social interactions and how people with disorders like autism, Williams, Rett's, Fragile X, and Timothy syndromes can vary in their ability to engage with others. Improvements are necessary...
In this article: Autism, Meningitis, and Fragile X
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Seaside Therapeutics Recruits Industry Veterans To Accelerate Development Of Candidates For Autism And Fragile X Syndrome
...Therapeutics. "They join an already exceptional team that is singularly focused on making a fundamental difference in the lives of individuals and their families affected by disorders such as Fragile X Syndrome and autism. With our core...
In this article: Autism and Medical advice
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Description from Wikipedia:
Fragile X syndrome, or Martin-Bell syndrome, is a genetic syndrome which results in a spectrum (from none to severe) of characteristic physical, intellectual, emotional and behavioural features. The syndrome is associated with the expansion (excessive repetition) of a single trinucleotide gene sequence (CGG) on the X chromosome, and results in a failure to express the FMR-1 protein which is required for normal neural development. There are four generally accepted forms of Fragile X syndrome which relate to the length of the repeated CGG sequence; Normal (29-31 CGG repeats), Premutation (55-200 CGG repeats), Full Mutation (more than 200 CGG repeats), and Intermediate or Gray Zone Alleles (40 - 60 repeats).
Martin and Bell in 1943, described a pedigree of X-linked mental disability, without considering the macroorchidism. In 1969 Chris and Weesam first sighted an unusual "marker X chromosome" in association with mental disability. In 1970 Frederick Hecht coined the term "fragile site" (Renpenning's syndrome is not synonymous with the syndrome). In Renpenning's syndrome there is no fragile site on the X chromosome. Renpenning's cases had short stature, moderate microcephaly, and neurological disorders.
Escalante's syndrome is synonymous with the fragile X syndrome. This term has been used in Brazil and other South American countries.
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