Paclitaxel
Chemotherapeutic Drug
Genasense(R) Given As High-Dose IV Infusion With Chemotherapy Shows Promising Activity In Advanced Melanoma...Genasense with temozolomide (Temodar®; Schering Plough, Inc.), the most commonly used anticancer drug for melanoma, and Abraxane® (paclitaxel protein-bound particles for injectable suspension [albumen bound]; Abraxis Bioscience, Inc.). In this article: Melanoma, Oblimersen, Temozolomide, Cancer, Bcl-2, Medical advice, and Taxane |
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PR Newswire: Technology | 1 day ago
Biophysics and Chemistry Research Honored at Nation's Premier High School Science Competition
...in Combating Chemotherapy Drug Resistance, uses state of the art computational techniques to develop a molecular understanding of how Taxol functions to kill tumor cells. "Mr. Jiang's results allowed him to predict the long range effects...
In this article: Chemistry, New York City, Biophysics, Carnegie Mellon University, and Physics
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Oncolytics Biotech(R) Inc. Announces Terms of Unit Offering
Oncolytics intends to use the net proceeds from the offering to fund its previously announced Phase III combination REOLYSIN(R) and paclitaxel/carboplatin trial for patients with platinum-failed head and neck cancers, its other...
In this article: Cancer, United States Securities and Exchange Commission, Oppenheimer & Co., Platinum, and Securities Exchange Act of 1934
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Reuters | 5 days ago
In Amazon, a frustrated search for cancer cures
...was researching the medical potential of the forest. JIGSAW PUZZLE Among the natural products being used to fight cancer today is Taxol, a chemotherapy drug that comes from the bark of the Pacific yew tree. David Newman, head of...
In this article: Cancer, Drauzio Varella, Sao Paulo, Captopril, AIDS, Taxol, and Malaria
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Centre Daily Times | 6 days ago
Exelixis Reports Encouraging Phase 1 Data for the PI3K Inhibitor XL147 (SAR245408) in Combination with Paclitaxel and Carboplatin at the AACR-NCI-EORTC Conference
...Inc. (Nasdaq:EXEL) today reported interim data from an ongoing phase 1 dose-escalation trial of XL147 (SAR245408) in combination with paclitaxel and carboplatin in patients with advanced solid tumors. XL147 is a selective, orally...
In this article: Carboplatin, Cancer, Platinum, Daiichi-Sankyo, Thrombocytopenia, Amplification, Biopsy, Anorexia, and Adenocarcinoma
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Prime Newswire | 6 days ago
OXiGENE Reports Positive Safety Data From Phase 2 Trial of ZYBRESTAT in Non-Small Cell Lung Cancer at the 2009 AACR-NCI-EORTC Conference
...cancer (NSCLC). The data from this planned interim safety analysis indicated that the combination of fosbretabulin with carboplatin and paclitaxel plus bevacizumab (Avastin(R)) appeared to be well-tolerated, and that there were no...
In this article: Bevacizumab, Lung cancer, Carboplatin, Cancer, Platinum, Anaplastic thyroid cancer, and Ovarian cancer
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Medical News Today | 6 days ago
Genentech Submits Supplemental Applications To FDA For Avastin Combined With Commonly Used Chemotherapies For Women With Advanced Breast Cancer
...treatment for advanced HER2-negative breast cancer (E2100, AVADO and RIBBON 1). - E2100: Avastin plus paclitaxel chemotherapy compared to paclitaxel chemotherapy alone (722 patients) - AVADO: Avastin plus docetaxel chemotherapy compared...
In this article: Bevacizumab, Breast cancer, FDA, Genentech, Surgery, Cancer, Taxane, HER2, and Capecitabine
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Oncolytics Biotech(R) Inc. Collaborators Present Positive Phase I/II Trial Results in Advanced Solid Cancers with a Focus on the Head and Neck at the AACR-NCI-EORTC Meeting
...NASDAQ:ONCY) ("Oncolytics" or the "Company") today announced updated results from a Phase I/II U.K. trial (REO 011) of REOLYSIN(R) combined with paclitaxel/carboplatin for patients with advanced cancers in a poster presentation at the 2009...
In this article: Cancer, Carboplatin, Platinum, Head and neck cancer, and U.S. Food and Drug Administration
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ASCO Releases Updated Treatment Guidelines For Patients With Stage 4 Non-Small Cell Lung Cancer
...in combination with a second drug, such as docetaxel (Taxotere), gemcitabine (Gemzar), irinotecan (Camptosar), paclitaxel (Taxol), pemetrexed (Alimta) or vinorelbine (Navelbine). - Bevacizumab (Avastin) is recommended with carboplatin...
In this article: Lung cancer, Cancer, Gefitinib, Erlotinib, Pemetrexed, Carboplatin, Irinotecan, and Gemcitabine
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Genta Announces Results of AGENDA Phase 3 Trial of Genasense® in Patients with Advanced Melanoma
...bone loss. The Company is developing tesetaxel, a novel, orally absorbed, semi-synthetic taxane that is in the same class of drugs as paclitaxel and docetaxel. Genta intends to evaluate the clinical activity of tesetaxel in a range of human...
In this article: Oblimersen, Melanoma, Cancer, United States, Gallium, European Medicines Agency, Taxane, and Dacarbazine
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Forbes.com Technology News | November 12, 2009
The Great Reaction
...new chemicals can be a laborious and time-consuming process. It took chemists two decades to figure out how to produce the cancer drug Taxol in the lab. Before that, it had to be derived from the bark of the Pacific yew tree. Sharpless aims...
In this article: K. Barry Sharpless, Coelacanth, Caltech, Nobel Prize in Chemistry, Copper, Carbon, Cancer, and Antibiotic
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More on Paclitaxel
Description from Wikipedia:
-1,9- dihydroxy-10,14,17,17-tetramethyl -11-oxo-6-oxatetracyclo [11.3.1.0~3,10~.0~4,7~] heptadec-13-en-2-yl benzoate
| image = Taxol.svg
| width = 350
| CAS_number = 33069-62-4
| ChemSpiderID = 10368587
| ATC_prefix = L01
| ATC_suffix = CD01
| PubChem = 36314
| DrugBank = APRD00259
| C=47 | H=51 | N=1 | O=14
| molecular_weight = 853.906 g/mol
| bioavailability = 6.5% (oral)
| protein_bound = 89 to 98%
| metabolism = Hepatic (CYP2C8 and CYP3A4)
| elimination_half-life = 5.8 hours
| excretion = Fecal and urinary
| pregnancy_AU =
| pregnancy_US = D
| pregnancy_category =
| legal_status = Rx-=only
| routes_of_administration = iv
}}
Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it 'taxol'. When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to 'paclitaxel' and the BMS compound is sold under the trademark 'Taxol'. In this formulation paclitaxel is dissolved in Cremophor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane.
Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.
Paclitaxel works by interfering with normal microtubule breakdown during cell division. Together with docetaxel, it forms the drug category of the taxanes. It was the subject of a notable total synthesis by Robert A. Holton.
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