Opioid
Painkiller and Psychoactive Drug
YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 INHIBITOR, CYT387 ENROLLED BY CYTOPIAYM is developing AeroLEF for the treatment of moderate to severe acute pain. The product is differentiated from other approaches using opioids because patients are able to individually control the analgesia required for their differing... In this article: JAK1, Cancer, Nimotuzumab, Mayo Clinic, and Dermatitis |
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Reuters | November 18, 2009
The depressed are more apt to get opioids for pain
...the researchers say more research is needed to understand the safety of prescribing opioids in depressed patients, and whether it's effective. Opioids are increasingly being prescribed to treat chronic pain that is not related to...
In this article: Depression, Back pain, Chronic pain, Codeine, Cancer, Arthritis, Morphine, and Ativan
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PR Newswire: Health / Biotech | November 17, 2009
The Cancer Pain Drug Market, Driven by the Continued Dominance of Opioids, Will Increase From $2.3 Billion in 2008 to $3.7 Billion in 2018
...Medical Pharmaceuticals, Pharmaceuticals, Surveys, Polls and Research The Cancer Pain Drug Market, Driven by the Continued Dominance of Opioids, Will Increase From $2.3 Billion in 2008 to $3.7 Billion in 2018 Breakthrough Pain Market...
In this article: Cancer, Fentanyl, Trademark, Morphine, Cephalon, Chronic pain, Zometa, and Monoclonal antibodies
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Par Pharmaceutical Receives Final Approval to Market Generic Ultram(R) ER
...be administered to patients who have previously demonstrated hypersensitivity to tramadol, any other component of this product or opioids. Tramadol hydrochloride ER tablets are contraindicated in any situation where opioids are...
In this article: Par Pharmaceutical, Tramadol, Analgesic, Ortho-McNeil, Safe harbor, Chronic pain, Private Securities Litigation Reform Act of 1995, and Narcotic
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Medical News Today | November 16, 2009
Depression Patients More Apt To Receive Opioids For Chronic Pain
...2009 - 1:00 PST Chronic pain patients with a history of depression are three times more likely to receive long-term prescriptions for opioid medications like Vicodin compared to pain patients who do not suffer from depression, according to...
In this article: Depression, Chronic pain, Mental disorder, Vicodin, University of Washington, and Group Health
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Abbott To Acquire Novel Investigational Biologic To Treat Chronic Pain
...and up to 30 percent of chronic pain patients get inadequate relief. Current treatments consist of NSAIDs, selective Cox-2 inhibitors, opioids and other analgesics that are dosed daily and have various tolerability and safety issues,...
In this article: Chronic pain, Vitamin D, Back pain, Nsaids, Analgesic, Cox-2, Cancer, and Osteoarthritis
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New York Times | November 05, 2009
Treating the Pain Epidemic
...Beth Israel Medical Center, was one of the pain experts who supported William Hurwitz, the Virginia doctor who was imprisoned for prescribing opioid painkillers to patients who resold them. (Dr. Hurwitz's sentence was reduced after a retrial...
In this article: Chronic pain, John Tierney, Surgery, and University of California, Los Angeles
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FDA aims to fight avoidable harm from medicines
...at the agency's headquarters in suburban Maryland. Improper use is one area FDA officials want to tackle. Even one dose of an opioid painkiller, for example, can kill if taken by someone other than the intended patient, the FDA...
In this article: Food and Drug Administration, Tylenol, Johnson & Johnson, and Pharmaceutical Research and Manufacturers of America
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Covidien Receives FDA Approval For Oral Transmucosal Fentanyl Citrate Product
...of fentanyl that resembles a lozenge on a handle. Oral Transmucosal Fentanyl Citrate, a Class II controlled substance, is an opioid analgesic indicated only for the management of breakthrough cancer pain in patients 16 years of age and...
In this article: Covidien, Fentanyl, FDA, Cancer, Pharmaceutical, Depression, Oxycodone, Morphine, and Hydromorphone
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Phase 2 Data From Oral NKTR-118 Presented At American College Of Gastroenterology In San Diego
...opioid market. Currently, there are no oral drugs approved that are indicated to treat opioid-induced constipation. Opioid bowel dysfunction and opioid-induced constipation can significantly impact quality of life and increase...
In this article: Constipation, AstraZeneca, Opiate, American College, Medical advice, Nektar Therapeutics, Derivative, and San Diego
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Risks of opioids for arthritis outweigh benefits
...Older folks looking to find relief from painful arthritis should steer clear of codeine, OxyContin and other powerful prescription "opioid" painkillers, even if their pain is severe, doctors advise in a report published this week. That's...
In this article: Arthritis, Oxycodone, Codeine, Oxymorphone, Osteoarthritis, Opiate, and Nausea
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Description from Wikipedia:
An opioid is a chemical substance that has a morphine-like action in the body. The main use is for pain relief. These agents work by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract. The receptors in these two organ systems mediate both the beneficial effects, and the undesirable side effects. There are a number of broad classes of opioids:
*natural opiates, alkaloids contained in the resin of the opium poppy including morphine, codeine and thebaine, but not papaverine and noscapine which have a different mechanism of action;
*semi-synthetic opiates, created from the natural opioids, such as hydromorphone, hydrocodone, oxycodone, oxymorphone, desomorphine, diacetylmorphine (Heroin), nicomorphine, dipropanoylmorphine, benzylmorphine and ethylmorphine;
*fully synthetic opioids, such as fentanyl, pethidine, methadone, tramadol and propoxyphene;
*endogenous opioid peptides, produced naturally in the body, such as endorphins, enkephalins, dynorphins, and endomorphins.
Although the term opiate is often used as a synonym for opioid, it is more properly limited to the natural opium alkaloids and the semi-synthetics derived from them.
Some minor opium alkaloids and various substances with opioid action are also found elsewhere in nature, including alkaloids present in the Kratom, Corydalis, and Salvia plants and some species of poppy aside from Papaver somniferum, and there are strains which produce copious amounts of thebaine, an important raw material for making many semi-synthetic and synthetic opioids. Of all of the more than 120 poppy species, only two produce morphine.
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