Glucocorticoid
Steroid
Merck Wins Summary Judgment in Second Federal Bellwether Case Involving FOSAMAX® (alendronate sodium)...observed in a one-year study in men with osteoporosis receiving once weekly FOSAMAX 70 mg. Glucocorticoid-induced Osteoporosis Sustained use of glucocorticoids is commonly associated with development of osteoporosis and resulting... In this article: Osteoporosis, Merck, Calcium, Glucocorticoid, Estrogen, Phosphate, Plaintiff, Vitamin D, and Nsaids |
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ScienceDaily: Latest Science News | November 20, 2009
Antioxidant found in vegetables has implications for treating cystic fibrosis
Breathe Deep: Which Patients Could Benefit From Inhaled Steroids In Cystic Fibrosis? (Nov. 30, 2007) A specific variation in the glucocorticoid receptor gene is associated with lung disease progression in cystic fibrosis, new research...
In this article: Cystic fibrosis, Thiocyanate, Hypochlorite, CFTR, Cardiovascular disease, Neurodegeneration, Maryland, University of Pennsylvania School of Medicine, and Burkholderia cenocepacia
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PR Newswire: Health / Biotech | November 12, 2009
Hollis-Eden to Present Interim Data From Its Phase I/II Clinical Studies of Apoptone(R) (HE3235) at Molecular Targets and Cancer Therapeutics Conference
...that Triolex was safe and well-tolerated, and there were no side effects observed such as those seen with testosterone, estrogen, progesterone or glucocorticoids. Diabetes Phase II two-stage exploratory and confirmatory trial HE3286-0401
In this article: Cancer, Methotrexate, Insulin, Metformin, Type 2 diabetes, Rheumatoid arthritis, Hormone, and Steroid
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Medical News Today | October 30, 2009
Teriparatide Outperforms Alendronate In Treating Steroid-Induced Osteoporosis
Article Date: 30 Oct 2009 - 0:00 PDT A recent study determined glucocorticoid-induced osteoporosis (OP) is now treatable with Teriparatide, a synthetic form of the human parathyroid hormone. Researchers found patients with...
In this article: Osteoporosis, Steroid, Inflammation, Calcium, Arthritis, Prednisone, and Vitamin D
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MedicineNet | October 30, 2009
Health Highlights: Oct. 29, 2009
...diet is affecting our immune systems." Immune-Suppressing Drugs May Boost Bladder Cancer Risk People who take immune-suppressing glucocorticoid drugs may be at increased risk for bladder cancer, according to a U.S. study.
In this article: Cancer, Asthma, FDA, IBM, Bladder cancer, United Press International, California, United States, and Naked mole rat
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MedicineNet | October 30, 2009
Better Drug Emerges for Steroid-Induced Bone Loss
...(HealthDay News) -- The drug teriparatide is better at increasing bone density and reducing vertebral fractures in patients with glucocorticoid-induced osteoporosis than the drug alendronate, a new study finds. Glucocorticoids are steroid...
In this article: Osteoporosis, Steroid, Calcium, Prednisone, Vitamin D, Dexamethasone, Crohn's disease, Cortisone, and Bone fracture
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Medical News Today | October 28, 2009
Do Drug Therapies Raise Risk Of Bladder Cancer?
...and with Karagas, a professor of community and family medicine at DMS, as principal investigator. The report examines the long-term use of glucocorticoids by 786 bladder-cancer patients and by 1,083 control subjects. Doctors commonly...
In this article: Bladder cancer, Cancer, British Journal of Cancer, Dartmouth Medical School, Surgery, and Asthma
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New Kerala | October 27, 2009
Immune system-suppressing drugs 'raise bladder cancer risk'
...case-control study in New Hampshire. Dartmouth epidemiologist Margaret R. Karagas and her team examined the long-term use of glucocorticoids by 786 bladder-cancer patients and by 1,083 control subjects. Doctors commonly prescribe a...
In this article: Bladder cancer, Cancer, British Journal of Cancer, Asthma, Rheumatoid arthritis, Skin cancer, Washington, and New Hampshire
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New Kerala | October 24, 2009
Ciggie smoke 'weakens lungs' natural defense against harmful pathogen'
...that cigarette smoke extract impaired the alveolar macrophage process. Additionally, cells exposed to cigarette smoke extract were treated with glucocorticoid, an anti-inflammatory drug commonly used to treat respiratory conditions, and...
In this article: Chronic obstructive pulmonary disease, Infection and Immunity, Chronic bronchitis, Respiratory disease, Meningitis, Sinusitis, Washington, UK, and Spain
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Centre Daily Times | October 21, 2009
CombinatoRx’S Synavive (CRx-102) Maintains Efficacy Throughout 12 Month Phase 2 Knee OA Extension Trial
...month core study in all WOMAC measurement subscales including pain, physical function and stiffness. Synavive is a novel dissociated glucocorticoid product candidate designed to enhance the anti-inflammatory benefits of glucocorticoids,...
In this article: Dipyridamole, Prednisolone, Osteoarthritis, Anti-inflammatory, Rheumatoid arthritis, Cambridge, Massachusetts, and Glucose
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Medical News Today | October 20, 2009
Winston Laboratories, Inc. Receives Notice Of Non-Compliance In Canada For Its New Drug Submission Of CIVANEX To Treat Osteoarthritis
...with osteoarthritis of the knee who have moderate-to-severe pain, and in whom signs of joint inflammation are present, intra-articular glucocorticoids can also be used. No picture of osteoporosis is complete without an understanding of...
In this article: Osteoarthritis, Arthritis, Inflammation, Nsaid, and Osteoporosis
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Description from Wikipedia:
Glucocorticoids (GC) are a class of steroid hormones characterised by an ability to bind with the glucocorticoid receptor (GR) and trigger similar effects. These may be either slow, mediated genomically through nuclear receptors, or fast, mediated nongenomically through membrane-associated receptors and signaling cascades. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by their specific receptors, target cells, and effects. In technical terms, corticosteroid refers to both glucocorticoids and mineralocorticoids (as both are mimics of hormones produced by the adrenal cortex), but is often used as a synonym for glucocorticoid.
Cortisol (or hydrocortisone) is the most important human glucocorticoid. It is essential for life, and regulates or supports a variety of important cardiovascular, metabolic, immunologic, and homeostatic functions. Glucocorticoid receptors are found in the cells of almost all vertebrate tissues. Various synthetic glucocorticoids are available; these are used either as replacement therapy in glucocorticoid deficiency or to suppress the immune system.
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