Polycystic kidney disease
Disease
Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer...human disease. The company's clinical stage programs include PLX4032 for the treatment of melanoma and colorectal cancer, PLX5568 for the treatment of polycystic kidney disease and PLX204 for the treatment of diabetes. Among the company's... In this article: Melanoma, Cancer, BRAF, First Data, Skin cancer, Competitive advantage, Targeted therapy, and Breast cancer |
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Polycystic kidney disease
Polycystic kidney disease — Comprehensive overview covers symptoms, ... have a first-degree relative — parent, sibling or child — with polycystic kidney ...
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www.clinicaltrials.gov
Adrenal Functions in Autosomal Dominant Polycystic Kidney ...
First Received: December 31, 2007 Last Updated: February 17, 2009 History of Changes ... Genetics Home Reference related topics: polycystic kidney disease ...
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www.felinecrf.org
Tanya's Feline CRF Info Centre - Related Diseases
... State University recommends treating with medication in the first instance. ... Autosomal Dominant Polycystic Kidney Disease in Persian Cats is an informative ...
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www.medworm.com
Polycystic Kidney Disease RSS
Recent data suggest that the etiology of kidney cysts involves aberrant ... This study provides the first directly functional evidence that PC-2 mediates ...
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www.ncbi.nlm.nih.gov
Polycystic Kidney Disease, Autosomal Dominant -- GeneReviews ...
... requested for ADPKD because the disease usually first occurs in adulthood. ... Animal data support the role of dietary protein restriction and careful control ...
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Polycystic Kidney Disease, Autosomal Recessive -- GeneReviews ...
... progress to end-stage renal disease (ESRD), usually in the first decade of life. ... No systematic data are available on the sensitivity and specificity of ...
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www.niddk.nih.gov
NIDDK : Clinical Research : Polycystic Kidney Disease (PKD ...
A sizable body of data supports the effectiveness of converting enzyme ... The first large interventional clinical trial in this network, called HALT-PKD, ...
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www.thedoctorsdoctor.com
Kidney-Polycystic Kidney Disease
METHODS: Data from 516 subjects with ADPKD (217 male and 299 female), aged ... kidneys was first described pathologically in 1841 and "polycystic kidneys" as ...
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www.medscape.com
Proof-Of-Concept Trial In Patients With Dominant Polycystic ...
Abstract and Background: The first randomized controlled trial to examine the effectiveness, safety and tolerability of sirolimus to retard disease progression in ...
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Description from Wikipedia:
Polycystic kidney disease (PKD, also known as polycystic kidney syndrome) is a progressive, ciliopathic, genetic disorder of the kidneys. It occurs in humans and other organisms. PKD is characterized by the presence of multiple cysts (hence, "polycystic") in both kidneys. The disease can also damage the liver, pancreas, and rarely, the heart and brain. The two major forms of polycystic kidney disease are distinguished by their patterns of inheritance.
Autosomal dominant polycystic kidney disease (ADPKD) is generally a late-onset disorder characterized by progressive cyst development and bilaterally enlarged kidneys with multiple cysts. Kidney manifestations in this disorder include renal function abnormalities, hypertension, renal pain, and renal insufficiency. Approximately 50% of patients with ADPKD have end-stage renal disease (ESRD) by the age of 60. ADPKD is a systemic disease with cysts in other organs such as the liver (which may lead to cirrhosis), seminal vesicles, pancreas, and arachnoid mater and non-cystic abnormalities such as intracranial aneurysms and dolichoectasias, dilation of the aortic root and dissection of the thoracic aorta, mitral valve prolapse, and abdominal wall hernias.
Initial simian and human symptoms are hypertension, fatigue, and mild to severe back or flank pain and urinary tract infections. The disease often leads to chronic renal failure and may result in total loss of kidney function, known as end stage renal disease (ESRD), which requires some form of renal replacement therapy (e.g. dialysis).
Autosomal recessive polycystic kidney disease (ARPKD) is much rarer than ADPKD and is often fatal in utero or during the first month of life. The signs and symptoms of the condition are usually apparent at birth or in early infancy.
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